Genetic polymorphism of human CYP2C subfamily

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منابع مشابه

Thalidomide metabolism by the CYP2C subfamily.

PURPOSE This research investigated the biotransformation of thalidomide by cytochrome P-450 (CYP). EXPERIMENTAL DESIGN We used liver microsomes from humans and/or animals and the recombinant specific CYP isozymes to investigate CYP-mediated metabolism of thalidomide. RESULTS Thalidomide was biotransformed into 5-hydroxythalidomide (5-OH) and diastereomeric 5'-hydroxythalidomide (5'-OH) by l...

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Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1998

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)40265-5